Axonal transport and neurodegenerative disease
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چکیده
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Axonal Transport and Neurodegenerative Diseases 1199 Axonal Transport and Neurodegenerative Diseases
The primary functions of the neuron are to receive, process, and transmit information. A typical neuron has multiple dendrites and a single elongated process, the axon. The dendrites and the cell bodies play a role in the collection and processing of information, and the axon is responsible for the transmission of information to other neurons via synapses. Whereas dendrites are usually in close...
متن کاملAxonal transport defects in neurodegenerative diseases.
Adult-onset neurodegenerative diseases (AONDs) comprise a heterogeneous group of neurological disorders characterized by a progressive, age-dependent decline in neuronal function and loss of selected neuronal populations. Alterations in synaptic function and axonal connectivity represent early and critical pathogenic events in AONDs, but molecular mechanisms underlying these defects remain elus...
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Gene products such as organelles, proteins and RNAs are actively transported to synaptic terminals for the remodeling of pre-existing neuronal connections and formation of new ones. Proteins described as molecular motors mediate this transport and utilize specialized cytoskeletal proteins that function as molecular tracks for the motor based transport of cargos. Molecular motors such as kinesin...
متن کاملAxonal transport and Alzheimer's disease.
In contrast to most eukaryotic cells, neurons possess long, highly branched processes called axons and dendrites. In large mammals, such as humans, some axons reach lengths of over 1 m. These lengths pose a major challenge to the movement of proteins, vesicles, and organelles between presynaptic sites and cell bodies. To overcome this challenge axons and dendrites rely upon specialized transpor...
متن کاملDiabetic Encephalopathy Affects Mitochondria and Axonal Transport Proteins
Introduction: Diabetic encephalopathy is described as any cognitive and memory impairments and associated with hippocampal degenerative changes, include neurodegenerative process and decreased number of living cell. Mitochondrial Diabetes (MD) appears fallowing activation of mutant mitochondrial DNA and is combination of diabetes and cognitive deficit. In this research we showed the correlation...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
سال: 2006
ISSN: 0925-4439
DOI: 10.1016/j.bbadis.2006.04.002